³Ô¹ÏÍø

Pre-clinical evaluation of anti-obesity and anti-diabetic agents – a complete service by experts

At the Institute for Biomedical and Bioscience Research (based at the Clore Laboratory)

The staff members are internationally recognised drug discovery experts and opinion leaders within the fields of obesity, diabetes and metabolic disease. The Clore Laboratory has a track record of successful pre-clinical and predictive evaluation of novel agents.

Advice on experimental design:

• On animal models: DIO mice and rats – ob/ob and db/db mice – fa/fa rats and ZDF rats – HFD/STZ mice
• On output measurements:
• energy expenditure and RQ
• thermic response to food
• basal metabolic rate at thermoneutrality
• body composition in mice by DEXA or NMR
• glucose tolerance, insulin tolerance and pyruvate tolerance
• euglycemic hyperinsulinemic clamps
• isolated hepatocytes and adipocytes
• isolated soleus muscle

Services available

• animal and human primary cells and cell lines
• systemic and central Inflammatory markers
• Oxidative stress markers
• metabolic parameters such as glucose, lactate, lipids
• hormones such as insulin, glucagon, GLP-1, and adipokines
• microarrays, RNA analysis and Western blots
• hepatic glucose output and tissue glucose uptake
• liver and muscle toxicology markers
• images analysis

For confidential enquiries about services available and quotations please contact: 

Professor Mohamed Zaibi
mohamed.zaibi@buckingham.ac.uk
+44 (0)1280 820370

IBBR. The Clore Laboratory, University of ³Ô¹ÏÍø, ³Ô¹ÏÍø MK18 1EG, UK